Job Properties
  • Job Type
    Full-time Position
  • Category
    Software & Information Technology
  • Languages
  • Experience Required
  • Degree Required
    • Province
    • Date Posted
      August 06,2021
    • JSS
    • VISA
    • IMG_6430
    • Career Consultation
    • CV CHECK

    Scientist Immunology/ Immuno-Oncology

    Application deadline:
    Expected Start Date:
    Penny de Villiers
    Company homepage:
    Office address:
    Microweg 22, 6545CM Nijmegen

    Are you eager to use your immunology expertise and in vivo preclinical experience to have impact on the development of new drugs?

    Your new role
    As scientist in the In Vivo Pharmacology, Toxicology and DMPK Department within Byondis’ Preclinical Research you will help drive our drug development efforts in immuno-oncology (IO). After building a deep understanding of the disease and biology around the therapeutic target, you will design preclinical in vivo studies to evaluate disease response, resistance and mechanisms of action and to demonstrate proof of principle of novel therapeutic candidates. You will outsource these studies to and collaborate with international contract research organizations and academic institutes.

    Your responsibilities
    For immunology-based questions related to in vivo models, you will be the source of information and subject matter expert within your department. You will set-up IO animal models that enable you to efficiently test new concepts and compounds, monoclonal antibodies and/ or antibody-drug conjugates in vivo. Your output includes proposing clear hypotheses, design and execution of clever experiments, interpretation and presentation of data in oral presentations, internally and occasionally externally at conferences but also in writing as internal reports, sections of regulatory filings and scientific papers. You will represent your department in multi-disciplinary teams.

    What you will need to succeed
    Candidates must have a PhD in a field of immunology and experience in basic or translational research either in an academic and/or industry setting. Experience with immunologically humanized mouse models, immune cell activation and/or characterization of tumors using FACS analysis is a plus. You must demonstrate a high level of independence and be able to develop hypotheses, translate these into focused experiments and execute these, based on a thorough understanding of disease and drug target biology. You have ample experience with in vivo experimentation and a strong commitment to the principles of the 3Rs (Replacement, Reduction and Refinement). The position requires working in close partnership across various disciplines and with external partners. Thus, strong communication skills are required, as evidenced by publications, meeting abstracts and/or contributions to regulatory documents. You have a proven track record of solving preclinical immunological research questions and as team player in a multidisciplinary team.

    We offer
    Byondis’ broad development portfolio comprises preclinical and early- and late-stage clinical programs, including the anti-HER2 ADC [vic-]trastuzumab duocarmazine (SYD985, Phase III). The company has a dedicated team of more than 350 staff including highly educated scientists and skilled technicians working in its state-of-the-art R&D and GMP manufacturing facilities in Nijmegen, the Netherlands. Byondis collaborates with global biotechnology and pharmaceutical companies and national and international academic research institutions and we offer you a dynamic and multidisciplinary working environment where your skills like a creative mind and critical view are fully in place.

    Information and application
    Contract hours: 32-40 hrs/week. Flexible working arrangements
    Salary: Competitive salary with benefits
    Required start date: ASAP
    First interviews will be scheduled on 1/09/2021 and second interviews on 7/09/2021

    What you need to do
    If you are interested in this role, 'click' apply to forward your up-to-date CV with a short motivational letter
    For further information, please contact Penny de Villiers

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