Job Properties
  • Job Type
    Full-time Position
  • Category
    Research & Science
  • Languages
  • Experience Required
  • Degree Required
    • Province
    • Date Posted
      September 25,2021
    • JSS
    • VISA
    • IMG_6430
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    Scientist Adult Neurology

    Location: Amsterdam (Netherlands)
    Job category: Research

    uniQure is dedicated to bring innovative therapies or unmet medical needs to patients. In doing so each function in uniQure is directly or indirectly responsible for the lives of patients. This responsibility should be part of our day-to-day working life by (i) living up to high quality standards and (ii) recognizing the sense of urgency in areas of high medical need.

    Purpose of the role

    We are looking for a highly motivated and inquisitive Scientist Disease Biology to support the development of (novel) gene therapies for the Amyotrophic Lateral Sclerosis (ALS) program.

    Place in the Organization

    The position is based in the Research Department (Amsterdam), within the CNS Disease Biology group.

    The key activities of the group are to develop novel gene therapy strategies for the treatment of CNS disorders of high unmet medical need. To this end, a deep understanding of underlying mechanisms of CNS disease and especially the ALS disease is needed, to be applied to the strategy and design of innovative therapeutic approaches. The Adult Neurology scientist is, together with the broader team, responsible of bringing scientific excellence to the ALS program. She/he is also responsible of developing novel methods, tailored to the known mechanism-of-action of each given gene therapy approach, aimed at showing therapeutic efficacy, in vitro and in preclinical studies.

    Key result areas (major duties, accountabilities and responsibilities)

    Synthesizes the input from a multidisciplinary project team in order to make decisions, and to set project priorities
    Participates in strategy, study design and implementation of dedicated mechanistic studies to understand basic questions on underlying biology of ALS, and gene therapy approaches with therapeutic potential
    Analyzes complex data obtained from pre-clinical studies (in vitro and in vivo)
    Strong (molecular) biological knowledge to understand obtained results and place them into the context of program development
    Hands-on laboratory and data analyses performed with little supervision
    Experience in supervising a small team of (jr.) technicians
    Brings up his/her ideas about the line of research and, upon mutual agreement, implements the new ideas and concepts, disseminates and reports the results
    Plans her/his own work, sets priorities and timelines and adheres to these timelines
    Is quality orientated (i.e. detail and data critical) and she/he evaluates her/his own behavior and corrects her/himself if needed. She/he proposes ways to improve quality and throughput
    Disseminates results to multiple internal stakeholders
    Writes reports for internal purpose, and if possible external purposes

    Qualifications & Skills

    Successfully completed PhD or equivalent, in cell biology, molecular biology or related topic, with proven strong knowledge in the field of neurodegenerative and/or neurocognitive disorders.
    Demonstrated experience in mechanistic studies in disease models
    Experience with next-generation sequencing approaches, proteomics and/or metabolomics would be advantageous, including single-cell approaches
    Experience in analysing complex datasets using informatic tools
    Experience with biomarker assay development, in vitro cell models, including iPSC, is highly advantageous
    Hands-on experience in writing, presenting, and reviewing in research documents (reports, patents, publications etc.)
    Excellent knowledge of the English language (verbal, written and scientific)
    Pro-active attitude, flexible and professional
    Excellent presentation and written skills

    Core competencies

    Outstanding planning and organizational capabilities to plan own workload
    Proactive attitude with high level of ownership and accountability
    Enthusiastic team player with strong interpersonal effectiveness and collaboration skills
    Strong analytical skills
    People management skills
    Clear communication and presentation skills in project teams and beyond
    Flexible to act in a highly dynamic and demanding environment
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