Research Technician 'Retina-on-Chip: Modeling and Treating Eye diseases in a dish'
3 years In this project, we aim to create a cellular system based on iPSC human cells to generate a retina-on-a-chip to understand disease mechanism(s) and assess therapeutics. You will work closely with a PhD candidate in order to generate and investigate several retinal cells using from induced pluripotent stem cells from patients suffering from different diseases to find proper measurable readouts. This work will be done in collaboration with the University of Twente and two industrial partners.
The eye is the window to the world around us. Losing vision either early or late in life is a significant burden for patients. Nowadays, molecular therapies for eye conditions are at the forefront of personalized medicine development. However, the eye is a very complex and specialized organ and the lack of relevant and robust models hampers the progress in understanding the disease mechanisms and designing effective treatments.
Tasks and responsibilities
Perform wet-lab experiments using standard molecular and cellular techniques such as (RT-)PCR, cloning, Western blot and cell culture.
Independently and critically analyze results.
Present and discuss the results at workgroup meetings.
The anticipated start date for this position is 1 November 2021. Working at Radboud university medical center means that you are ahead of the curve and working together on the healthcare of the future. And there is more. Our secondary terms of employment are impressive. These are fully tailored to you thanks to our Employment Conditions Selection Model. At Radboud university medical center, you will be given trust, and you will take the responsibility to handle everything together. We provide annual courses, both professional and personal.
In addition to your monthly salary and an annual vacation allowance of 8%, you will receive an end-of-year bonus of 8.3%.
If you work irregular hours, you will receive an allowance.
As a full-time employee (36 hours per week), you are entitled to approximately 168 vacation hours (over 23 days) per year.
Radboud university medical center pays 70% of the pension premium. You pay the rest of the premium with your gross salary.
You get a discount on health insurance as well: you can take advantage of two group health insurance plans. UMC Zorgverzekering and CZ collectief.
In addition to our terms of employment, we also offer employees various other attractive facilities, such as childcare and sports facilities. Want to learn more? Take a look at the CAO UMC. You will be affiliated with the department of Pediatrics, and will conduct the experimental work in the department of Human Genetics. Radboud university medical center is internationally renowned for its research and diagnostics on a variety of genetic disorders and the impact of personalized medicine. Both departments offer an exciting working environment with enthusiastic people from many parts of the world, providing ample critical mass and a stimulating, collaborative atmosphere for high quality research.
You will be positioned within the “Molecular Therapies for Neurometabolic Diseases” group led by Dr. Alex Garanto, that aims to develop models and therapeutic interventions for inherited metabolic and eye diseases. There will be close collaboration with the group of “Molecular Therapies for Inherited Eye Diseases” led by Dr. Rob Collin, with whom we share lab and expertise. More information on these groups can be found here. There will be also collaborations with the Translational Metabolic Laboratory and the Department of Ophthalmology. In addition, you will work in close collaboration with a PhD candidate, and with colleagues at the University of Twente.
This project is funded by the Partnership programme Human Measurement models 2.0 for research into the treatment and/or prevention of diseases is funded by the Association of Collaborating Health Foundations (SGF) with a PPP allowance made available by Health~Holland (Top Sector Life Sciences & Health), by ZonMw and NWO Domain AES, and Stichting Proefdiervrij.
Radboud university medical center is a university medical center for patient care, scientific research, and education in Nijmegen. Radboud university medical center strives to be at the forefront of shaping the healthcare of the future. We do this in a person-centered and innovative way, and in close collaboration with our network. We want to have a significant impact on healthcare. We want to improve with each passing day, continuously working towards better healthcare, research, and education. And gaining a better understanding of how diseases arise and how we can prevent, treat, and cure them, day in and day out. This way, every patient always receives the best healthcare, now and in the future. Because that is why we do what we do.
Read more about our strategy and what working at Radboud university medical center means. Our colleagues would be happy to tell you about it. #weareradboudumc We are looking for a research technician who has relevant education and/or hands-on lab experience. This experience includes basic molecular and functional techniques at DNA, RNA, protein and cellular levels (PCR, cloning, RT-PCR, Western Blot, cell culture and immunocytochemistry amongst others) as well as experience with cell culture and stem cells. Previous experience in eye research, organoids or molecular therapies will be considered a plus.
Our ideal candidate has a result-oriented attitude, is flexible, and able to work in an independent manner as well as in a team. All additional information about the vacancy can be obtained from dr. Alex Garanto, assistant professor Pediatrics. Use the Apply button to submit your application.