Job Properties
  • Job Type
    Full-time Position
  • Background
    Other Science and Tech
  • Languages
  • Experience Required
    1 - 2 Years
  • Degree Required
    • Province
    • Date Posted
      October 03,2020
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    The postdoctoral fellow will be responsible for the coordination and execution of the study on Lgr-positive cells in mice and human tissue. The candidate will collaborate with other investigators and the research technician of our laboratory. Further responsibilities include supervision of Ph.D. students and students involved in the research program, the publication of the results and acquisition for funding for the continuation of the study. On various research meetings in and outside the department the postdoctoral fellow will discuss the progress of the study.


    In the department of Otorhinolaryngology and Head & Neck Surgery of the UMC Utrecht we perform cochlear implantation in patients with profound hearing loss or complete deafness in order to restore hearing. The research in our laboratory has long been aimed at improving hearing with a cochlear implant. Among others, we study neurotrophic treatment of the auditory nerve combining histological and electrophysiological methods in animals and humans. Recently, we expanded our interests towards regeneration of sensory cells in the cochlea aimed to restore hearing in patients without the need of an electronic device, and therefore we have set up a stem cell lab. We are interested in the behavior of cells that have potential stem cell properties (Lgr positive cells) in the mammalian cochlea, with the particular emphasis on their role in damage and repair. Lgr5 expression may represent a global marker for adult stemness. Potentially, generation of Lgr positive cells by WNT can result in restoration of cochlear sensory cells. The role of Lgr receptors needs to be further explored in the normal-hearing and deafened mammalian cochlea. The research of our department, in laboratory and in clinic, is multidisciplinary with contributions from physicians, biologists and physicists. The interaction that exists between the various disciplines in our department creates an environment where scientific advancements quickly move from bench to bedside and vice versa.


    A recent Ph.D. (or a Ph.D. expected shortly) in biology, biomedical sciences, neurosciences or comparable with a publication record relevant to stem cell research. We look for a candidate with scientific ambition and a desire to conduct and publish world-class research, who is capable running a laboratory, and who likes teamwork.

    The maximum salary for this position (36 hours) is € 4.615,00 gross per month based on full-time employment (work week 36 hours).

    In addition, we offer an annual benefit of 8.3%, holiday allowance, travel expenses and career opportunities. The terms of employment are in accordance with the Cao University Medical Centers (UMC).

    More information

    If you have any questions about this vacancy, please contact Mrs.Louise Straatman, KNO arts, phone number: 088-7556644, e‑mail adress:

    Acquisition based on this jobopening is not appreciated.

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