Job Properties
  • Job Type
    Full-time Position
  • Category
    Research & Science
  • Languages
    English
  • Experience Required
    Entry
  • Degree Required
    Bachelor
    • Province
      Amsterdam
    • Date Posted
      October 05,2021
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    Post-doc

    Location
    Amsterdam
    Working week
    36 hour

    Education
    PhD
    Closing date
    25 October 2021

    Function area
    Research / Laboratory
    Vacancy nr.
    6385

    The position

    The postdoc will work on a shared project in the research groups of Prof. Dr. Thorbald van Hall within the Department of Medical Oncology and Dr. Klaas van Gisbergen at Sanquin Research. The aim of our program is to implement immunotherapy as treatment modality for patients with solid tumors and is focused on the exploration of key factors in host-tumor interactions that lead to successes in immune control of cancer. You will be working on a research project and your tasks will include the planning and design of experiments, supervision of co-workers, writing research manuscripts and to present the data on national and international conferences.


    The project

    In this project we aim to understand the role of tissue-resident memory T cells in the immune defense against cancer. It is a collaboration between the research groups of Prof. Dr. Thorbald van Hall and Dr. Klaas van Gisbergen at Sanquin Research in Amsterdam and funded by the Dutch Cancer Society (KWF). Tissue-resident memory T cells are strategically positioned in tissues instead of the circulation to quickly respond to incoming pathogens. A well-defined differentiation program instructed by the transcription factors Hobit and Blimp-1 imprints tissue residency in these T cells. Given recent indications that tissue-resident memory T cells are relevant to counter tumor growth, we will explore these T cells in tumor immunity using a unique Hobit reporter/deleter model, allowing the specific visualization and manipulation of tissue-resident memory T cells. The research will be performed using state-of-the-art techniques in in vivo models, flow cytometry and transcriptional profiling.


    The department

    Leiden University Medical Center (LUMC) is a modern knowledge center with over 7,000 staff members who are passionate about combating disease and improving patient care through scientific research. The Cancer Immunology and Therapy research group is a young and successful team within the Department of Medical Oncology. We perform several types of fundamental, translational and clinical studies. A major focus of our group concerns the reinforcement of tumor-specific T cells using vaccines, immune modulatory antibodies and adoptive T cell transfer and is geared towards the exploration of tumor-specific antigens (neoepitopes, TEIPP and viral oncoproteins) and studies of T cell function in an immune suppressive microenvironment. Our institute offers a large number of core facilities and a broad immunological research environment with national and international collaborations.


    Sanquin Research is a large research institute with several departments including Hematopoiesis in which the resident memory T cell group operates. The group focuses on the development of memory CD8 T cells in infection and tumor settings and the transcriptional and molecular pathways underlying CD8 T cell differentiation. The eventual goal is to improve employment of CD8 T cells for the purpose of cancer immunotherapy. Sanquin provides a lively, internationally oriented, scientific environment with excellent facilities. The research is strongly multidisciplinary and includes molecular biology, flow cytometry, fluorescence microscopy and high throughput techniques (mass spectrometry, sequencing).


    Your profile

    • We are looking for an enthusiastic colleague with a PhD in immunology, who is highly motivated and has a proven interest in immunology and oncology.
    • Preferably, you have a number of years of postdoc experience leading research projects, however, starting postdocs are also encouraged to apply to this vacancy.
    • You take initiative and perform well in a team and preferably have hand-on experience with animal experimentation and multi-color flow cytometry and/or transcription profiling.
    • The ability to publish and present the results of your research is essential.

    We offer

    • salary and working conditions conform CAO Sanquin (FWG 55);
    • Temporary position for the duration of 3 years, of which 1,5 years at Sanquin Research in Amsterdam;
    • a full time contract of 36 hours per week;
    • 8,33% end-of-year bonus and 8,33% holiday allowance;
    • partial reimbursement of travel expenses;
    • pension plan with Pensioenfonds Zorg & Welzijn (PFZW);
    • collective discounts on various insurances;
    • at fulltime employment 201 hours of leave per annum

    More information

    For further information, please contact Dr. Klaas van Gisbergen (Sanquin Research, k.vangisbergen@sanquin.nl, telephone +31 (0)6 52 89 08 09) or Prof. Dr. Thorbald van Hall (Department of Medical Oncology, t.van_hall@lumc.nl, telephone +31 (0)71 526 6945). Does this vacancy trigger you and do you recognize yourself in this profile? We would like to receive your application, accompanied by curriculum vitae and cover letter, including a detailed motivation, before the 26th of October 2021. Please apply using the button below! Giving a presentation is part of the application procedure.


    Sanquin does not accept unrequested help from agencies for this vacancy. cv's (in whatever shape or form) that are send by agencies to any employee of Sanquin without a written assignment of a corporate recruiter, will be considered property of Sanquin and Sanquin will therefore not owe compensation in any way.

     
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