uniQure is dedicated to bring innovative therapies or unmet medical needs to patients. In doing so each function in uniQure is directly or indirectly responsible for the lives of patients. This responsibility should be part of our day-to-day working life by (i) living up to high quality standards and (ii) recognizing the sense of urgency in areas of high medical need.
Purpose of the role
The ideal candidate should have a deep knowledge of in vivo biology, in particular behavioral phenotyping assays, and analysis of administered gene therapy in terms of both efficacy and mechanism of action. The successful candidate will have strong written and oral communication skills. We are looking for a highly motivated and skilled scientist with a strong background in biology to join our team.
Place in the Organization
The In Vivo Biology Group has two functions and responsibilities (a) design, execution, and reporting of efficacy in vivo studies in rodents (including dose-range finding studies), as well as (b) sample analysis to get to lead selection. The group is based in Amsterdam and Groningen, NL.
Key result areas (major duties, accountabilities and responsibilities)
Formulates, initiates and implements research plans, together with the head of In Vivo Biology, for proof-of-concept studies which can be either requested by uniQure projects or necessary for improvement of existing technologies or develop new technologies
Perform in-house in vivo studies utilizing behavioral, imaging/microscopy and electrophysiological assays
Coach a team of in vivo technicians and teach routine procedures such as dosing, bleeding, tissue collections, and necropsies, monitor animal health, run behavioral assays, collect and record data
Organizing a robust communication line to all other relevant function of the organization
Organizes appropriate documentation e.g. study plans/reports and facilitates writing of regulatory documents
Qualifications & Skills
PhD in biology, pharmacology, neuroscience or related field with at least 5 years of in vivo biology and/or gene therapy experience
Proven scientific experience, preferably trained within the field of in vivo biology, neurobiology, neuropharmacology, immunology, gene therapy, and/or virology is a plus
Animal experience (art. 9 / 12 / 13f Dutch law on animal experimentation) and deep knowledge of small animal behavior and neurophysiology is required
Experience with handling of animals, animal tissues and biofluids for DNA, RNA and protein analysis under Microbiological Safety Level II restrictions
Proven track record working with in vivo disease models and deep experience in performing and analyzing behavioral studies
Hands-on experience in writing, presenting, and reviewing in research documents (reports, patents, publications etc.)
Strong communication skills (oral and written)
Experience with working in a fast changing and demanding environment, willing and able to act a pro-actively.
Creativity and explorative thinking
Ability to develop new working methods or new applications
Focus on flexibility, to act in a fast changing and demanding environment
Good communication skills
Ability to manage own workload as well as workload of co-workers
Pro-active attitude, flexible, professional
Strong team player
Ability to explain complex technical issues, question, and answers in writing and orally to persons not familiar with the subject
Ability to direct reports of own team