Postdoc in Genetic Mechanisms of Anti-Cancer Drug Resistance
We offer a Postdoc position in the division of Cell Biology, Metabolism, and Cancer in the Department of Biomolecular Health Sciences at the Faculty of Veterinary Medicine of Utrecht University. You will become part of a multidisciplinary research team of researchers led by Dr. Bart Westendorp (cell cycle & single cell analysis) and Prof. Alain de Bruin (molecular pathology & cancer). You will work on a project which aims to unravel novel genetic adaptation mechanisms that lead to resistance against anti-cancer therapeutics and explore strategies to block these mechanisms. Tumor cells are heterogeneous and individual cancer cells that become insensitive to therapeutics often causing disease relapse. This process resembles Darwinian evolution, but mounting evidence suggests that cancer cells can actively alter the genomes to accelerate this adaptation process. Understanding and targeting these processes may hold a promise for new therapeutic approaches to improve the prognosis of cancer patients.
In this Postdoc position, which is partly funded by the Dutch Research Council (NWO), you will focus on two different putative genetic adaptation mechanisms: (1) horizontal gene transfer via extracellular vesicles and (2) endogenous gene duplication via polyploidization. The project has a strong cell biology component, and will involve FACS-sorting, isolation and characterization of extracellular vesicles, DNA analysis, CRISPR/Cas9 screening, confocal microscopy, and live cell imaging. The research team is part of the Regenerative Medicine Center Utrecht, and is located in the Hubrecht Institute. You will work in a very lively and inspiring research environment surrounded by outstanding research labs. In addition, you will have access to state-of-the-art research facilities including single cell analysis, imaging, flow cytometry, and biobanks with patient materials localized at the Utrecht Science Campus in the Netherlands.
We offer a challenging position in a dynamic and professional environment with plenty of room for initiative and entrepreneurship. This position offers many opportunities to develop your talents, which will benefit your career. You will receive coaching and feedback from your colleagues on a regular basis, and there are multiple opportunities to follow specific courses and training programmes within the Utrecht University Development programme.
In this position you will:
design and conduct the experimental work for this research project;
write high-quality research publications;
write and contribute to research proposals for receiving additional external research funding;
contribute to research projects of our other team members, and/or other research groups;
supervise research projects of Master's and Bachelor's students.
Profiel To be successful in this position you:
are an ambitious and curiosity-driven junior scientist;
hold a PhD degree, preferably in the field of Biomedical Sciences or Biology;
have proven skills in cell culture and molecular biology techniques, as well as FACS sorting and confocal microscopy;
have experience with isolation and characterization of extracellular vesicles;
have knowledge in the field of cancer research, preferably ovarian or liver cancer;
have proven English presenting and writing skills and you can communicate clearly and effectively;
are a team player who is enthusiastic to collaborate with other team members and research groups;
are a creative thinker with a preference for high risk - high gain projects.
Aanbod We offer a Postdoc position (1.0 FTE) for three years, starting with a one year contract. An extension is possible if performance is satisfactory. The gross salary ranges between €2,836 and €4,474 (scale 10 according to the Collective Labour Agreement Dutch Universities) per month for full-time employment. Salaries are supplemented with a holiday bonus of 8% and a year-end bonus of 8.3% per year. In addition, Utrecht University offers excellent secondary conditions, including an attractive retirement scheme, (partly paid) parental leave and flexible employment conditions (multiple choice model). More information about working at Utrecht University can be found here.
Over de organisatie
A better future for everyone. This ambition motivates our scientists in executing their leading research and inspiring teaching. At Utrecht University, the various disciplines collaborate intensively towards major societal themes. Our focus is on Dynamics of Youth, Institutions for Open Societies, Life Sciences and Sustainability.
The Faculty of Veterinary Medicine has a unique position in the Netherlands. Not only is this the only institution where veterinarians are trained, researchers are also working together on innovative scientific research. In the coming years, the faculty will focus on three themes: One Health, One Medicine and Veterinary Biomedicine. In addition, the faculty provides specialist clinical care in the largest academic veterinary hospital in Europe. A focus on disease, health and well-being of animals and their environments underpins the faculty’s three main pillars: education, research, and veterinary health care. The faculty counts 1,500 students and 900 employees.
Utrecht University (UU) is founded in 1636 and is one of the largest universities in the Netherlands, it has over 8000 staff and 31,600 students. UU has the largest Graduate School in Europe, with over 1750 PhDs only within the Life Sciences Graduate School (GS-LS) – an interdisciplinary and cross-faculty PhD programme. The Faculty of Veterinary Medicine has 400 researchers including 180 PhD fellows and is the only Veterinary Knowledge Centre in the Netherlands and one of the highest-ranked worldwide (ranked 4th in QS World University Rankings 2020). The Faculty's research efforts are concentrated in three thematic interdisciplinary research programmes, embedded within the University-wide Life Sciences programme. The Faculty's research programmes are: One Health – focused on the relationship between animal, human and environment; One Medicine – focused on parallels between human and veterinary medicine; Veterinary Biomedicine – aimed at genesis, diagnosis and treatment of animal diseases. The Department of Biomolecular Health Sciences, one of three departments within the Faculty of Veterinary Medicine has 166 FTE employees including 50 PhD students. The department includes the three divisions Pathology, Infection & Immunity as well as Cell Biology, Metabolism & Cancer.
Additional information about the vacancy can be obtained from Bart Westendorp (Assistant Professor), via email@example.com of (030) 2535252.