Job Properties
  • Job Type
    Full-time Position
  • Category
    Research & Science
  • Languages
  • Experience Required
  • Degree Required
    • Province
    • Date Posted
      January 21,2022
    • Entrusting Package
    • JSS
    • VISA
    • IMG_6430
    • Career Consultation

    PhD Washing the brain during sleep

    About the role

    Several types of dementia are characterized by accumulation of toxic waste products. At present, it is not clear how waste is removed from the brain and how this fails in disease. However, there is recent evidence that perivascular spaces may contribute to brain clearance. These spaces are unique for the brain and may facilitate waste clearance most effectively during sleep.


    • A master of science degree in Biomedical Sciences, Biology, Neuroscience, Cardiovascular sciences, or similar.
    • Experience with experimental research in the field of neurology or the cardiovascular system is an advantage.
    • Experience with microscopy is an advantage.

    Our offer

    • We offer training in a PhD trainee program and create opportunities for career development PhD Safety Net infographic (
    • We offer a 4-year (PhD) contract starting with 12 months, which will be extended to another 36 months when positively evaluated.
    • We offer further training in a PhD trainee program and create opportunities for career development.
    • The salary is conforming the CAO-UMC’s, starting at € 2.570 on a full-time basis in year one, increasing towards € 3.271 in the 4th year.
    • In addition to a good basic salary, we offer an 8.3% year-end bonus and 8% holiday pay.
    • Your pension is built up with ABP; the Amsterdam UMC contributes a large part of the premium (70%).
    • Besides excellent accessibility by public transport, we reimburse 75% of your public transport costs and have a lucrative bicycle-plan.

    About the project

    In this project you will perform preclinical studies on perivascular spaces of the rodent brain using 2-photon microscopy and other techniques. You will investigate the anatomy of perivascular spaces and elucidate the driving forces for clearance in this system. These could be cardiac pulsations, breathing, or vascular contractions. Particular interest will be directed to the role of sleep, which may promote clearance through currently unknown mechanisms.

    About the workplace

    Working at Amsterdam UMC takes place in an inspiring and professional environment where development in every form is encouraged.

    You will work in an enthusiastic team of researchers who share their interest for the cerebrovascular system. We study stroke, micro-infarcts, hypertension, and perivascular spaces using cutting edge technology such as 2-photon imaging, MRI, ultrasound, and an in house developed imaging cryomicrotome setup.

    The project is part of a collaborative effort with Leiden University Medical Center, where a human counterpart of the current project is carried out. This provides a true translational framework that is expected to increase the impact of the project.

    Let's meet

    For more information about this position please contact Dr. Erik N.T.P. Bakker, Dept. Of Biomedical Engineering and Physics, via

    For more information about the application process please contact Tanja Hart, Recruitment adviser, via or via 06-21603178.

    A reference check, screening and hiring test may be part of the procedure. Read hier whether this also applies to you. If you join us, we ask for a VOG (Certificate of Good Conduct).

    Acquisition in response to this vacancy is not appreciated.

    Open Positions from Amsterdam UMC
    Related positions