Understanding how the immune system interacts with cancer is crucial for effective cancer immunotherapy. Clinical and epidemiological data suggests a protective effect of vitiligo against melanoma and other forms of skin cancer. Our ongoing research line has demonstrated that vitiligo can suppress the growth of melanoma. In this PhD project, you will explore the question how autoimmunity of the skin can inhibit the growth of various types of skin cancers, including basal cell carcinoma, squamous carcinoma of the skin and melanoma.
This research project is embedded in the scientific fields of cancer immunology and biology and autoimmunity. You will be part of the research team at the department Dermatology. You will perform in vitro research using patient-derived immune and tumor cells, as well as in vivo experiments using relevant mouse models. For the immunological analyses, you will use flow cytometry (FACS) and cytoxicity assays (e.g. IncuCyte). For a better understanding of tumor tissue biology and immune cell infiltration, you will acquire experience in advanced technologies, such as using Opal multiplex immunohistochemistry, Imaging Mass Cytometry (Hyperion) and RNAseq. In addition, as part of our ongoing research line, you will investigate the synergy of monobenzone-imiquimod immunotherapy in vivo in a pre-clinical melanoma model.
We are looking for a highly motivated and enthusiastic PhD student with a strong interest in immunology and oncology.
You have a University Master of Science (MSc) degree in a relevant study, during which you received excellent scientific research training in immunology, preferably by a successful research internship. Knowledge of oncology is a plus.
You are article 9 (FELASA) certified. Practical experience in animal (mouse) work is a plus.
You have outstanding experimental research skills and academic skills, are well organized, goal-oriented and results-driven, and have a strong team spirit, but you can also function independently.
You have good communication skills and good English scientific language skills .
A jump start to your career in research work.
All te space for you to contribute shaping the care of tomorrow.
Working on large-scale and research project, with motivated colleagues from all over the world.
A contract for one year (12 months) with the intention to extend for another 36 months.
Additional benefits include an 8.3% end-of-year bonus and 8.0% holiday pay.
The base salary does not include holiday pay (8%) and a year-end bonus (8.3%).
In addition to excellent accessibility by public transport, AMC also has a sufficient number of parking spaces for employees.
Pension is accrued at Be Frank.
About the project
This research project is funded by a research grant and by collaboartion with industrial partners. This project focusses on a challenging new hypothesis with high impact potential for dermato-oncology, since immunotherapy is now also being developed for the treament of non-melanoma skin cancer. This project contains translational research in immunology and oncology. The project has a well-defined plan of work, but also allows the exploration of more fundamental or new research questions based on the research findings. In addition, the project harbours an extension of our ongoing research line on the development of vitiligo-inducing immunotherapy for melanoma.
This project thereby provides an attractive opportunity for a PhD in cancer immunology.
About the workplace
The Laboratory of Expermental Dermatology (LED) of the department of Dermatology is specialized in translational and immunological research on pigment cell disorders of the skin, including vitiligo and melanoma. You will work in the LED research team consisting of research technicians, postdocs, PhD students and research staff members. The LED team closely collaborates with clinical staff members, which is essential for input from the clinic in the research and access to patient tissues for research. The LED is located at the department of Medical Biology, with state-of-the-art research facilities. The department of Dermatology of the Amsterdam UMC is the NFU acknowledged national center of expertise for pigment cell disorders, which creates an inspiring environment of clinical and scientific expertise for translational research.
The department of Dermatology is part of the Cancer Center Amsterdam (CCA) and the Amsterdam Institute for Infection and Immunity (AII) which both offer an excellent scientific and social environment for researchers. These research institutes organise seminars, symposia, retreats and networking events, as well as a yearly PhD-retreat for PhD students. Amsterdam UMC provides guidance for PhD students via the Doctoral School and a wide range of courses on scientific topics and skills and career development.
The first round of interviews will take place in mid-January. During the publication period of this vacancy, an invitation for a first interview is already possible.
Do you have any questions? For more information, please contact Prof. Dr. R.M. Luiten via email@example.com
For more information about the application process please contact Tanja Hart, Recruitment adviser, via firstname.lastname@example.org or via 06-21603178.
A reference check, screening and hiring test may be part of the procedure. Read hier whether this also applies to you. If you join us, we ask for a VOG (Certificate of Good Conduct).