Job Properties
  • Job Type
    Full-time Position
  • Category
    Research & Science
  • Languages
    English
  • Experience Required
    Entry
  • Degree Required
    Bachelor
    • Province
      Utrecht
    • Date Posted
      December 18,2021
    • Entrusting Package
    • JSS
    • VISA
    • MOCKINTERVIEW
    • IMG_6430
    • Career Consultation
    • COVERLETTER CHECK

    PhD position in Virtual Human Platform for Safety project

    Imagine a world in which we perform precision safety testing of chemicals and pharmaceuticals without using laboratory animals. Imagine that the safety of chemicals and pharmaceuticals can be assessed for vulnerable groups such as infants, the elderly or the diseased. Imagine that we know how these substances interact with human biology and physiology and how they can be used safely at home, school or at work during the course of our lives. This is our vision for the future, the vision that underlies the development of the Virtual Human Platform for Safety Assessment (VHP4Safety), the world’s first platform to determine the safety of chemicals and pharmaceuticals for human health based solely on human biology. By integrating innovations in data science, human tissue culture models and transition management, VHP4Safety will spearhead the transition to animal-free safety assessment. The VHP4Safety consortium consists of leading scientific groups from Dutch universities, university medical centres, public health institutes and applied research organisations, with expertise spanning the technological, biological, chemical, medical as well as the social sciences. The co-funders and cooperation partners ensure the active involvement of diverse academic, regulatory, industrial and societal partners to the project throughout the entire safety assessment knowledge chain.

    This research project is funded by the Dutch Research Council (NWO) 'Dutch Research Agenda: Research on Routes by Consortia' (NWA-ORC 1292.19.272). With a budget of over 10 million Euros, the project started on June 1, 2021 and will last for 5 years.

    The VHP4Safety project is made up of three interacting research lines (RL), that involve building the platform (RL1), feeding the platform with newly generated data (RL2) and implementing the platform (RL3) to ensure stakeholder acceptance, governance and sustainability.

    We have a vacancy for a PhD position in RL2, Work Package 2.2: Feeding the platform: Case study Kidney Disease. Human in vitro experimental models will be applied to feed the VHP with data on exposure, kinetics including metabolism, biological processes and toxicological effects. Data both on toxicokinetics and toxicodynamics will be generated by performing well-defined experiments with advanced in human vitro models. For human exposure data, clinical and epidemiological data will be collected and assessed. WP2.2. will study disease and pharmacovigilance by modelling kidney disease as a case study in the VHP. We will apply human-adult stem cell derived organoids cultured under microfluidics, that closely mimic healthy human kidney proximal tubules (named tubuloids), as well as patient-derived organoids, that will be exposed to nephrotoxic drugs. With these models we will study nephrotoxic pathology and predict acute kidney injury in specific patient groups, which will be translated to in silico models and validated with available human clinical data as input into RL1

    Department

    The VHP4Safety consortium consists of leading scientific groups from Dutch universities, university medical centres, public health institutes and applied research organizations, with expertise spanning the technological, biological, chemical, medical as well as the social sciences. The co-funders and cooperation partners ensure the active involvement of diverse academic, regulatory, industrial and societal partners to the project throughout the entire safety assessment knowledge chain.


    The Department of Nephrology & Hypertension is part of the Division of Internal Medicine and Dermatology. We provide academic, acute and chronic care to people in all stages of renal failure covering a range of renal replacement therapies including hemodialysis, peritoneal dialysis, and transplantation. We also perform excellent translational research which is embedded within the Strategic Programs Regenerative Medicine & Stem Cells and Circulatory Health. Our Research Laboratory is part of the Regenerative Medicine Center Utrecht (RMCU), where Regenerative Medicine researchers from many different disciplines in Utrecht work together, providing an inspirational environment, fostering open innovation and close collaboration. We aim to train the next generation of clinicians and scientists by offering stimulating and excellent education.

    Profile

    You have a master’s degree in life sciences, biomedical sciences, or a related field. You have affinity with cell culture and nephrology. You are highly motivated to work in a multidisciplinary environment of clinicians, biologists, physiologists. Experience with (organoid) cell culture, imaging, renal diseases are of benefit. You are fluent in English, both in speech and writing.


    We believe in the power of a diverse team in which there is room for different skills, expertise, and social and cultural backgrounds. We invite you to respond to this vacancy.

    The maximum salary for this position (36 - 36 hours) is € 3.196,00 gross per month based on full-time employment.

    In addition, we offer an annual benefit of 8.3%, holiday allowance, travel expenses and career opportunities. The terms of employment are in accordance with the Cao University Medical Centers (UMC).

    More information

    If you have any questions about this vacancy, please contact Marianne Verhaar, Professor of Experimental Nephrology, phone number: 0887557329, e‑mail adress: secretariaat-nefrologie@umcutrecht.nl.

    Acquisition based on this jobopening is not appreciated.

     
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