Leptin has been proposed as therapy for eating disorders (to assist dieting in obesity as well for treatment in anorexia nervosa patients). In order to unravel how beneficial effects of leptin are mediated you will take a molecular neuroscience approach and address via which neurons and neural circuits beneficial effects of leptin are mediated. You will target leptin responsive neurons with viral vectors and unravel their function using Crispr/Cas, fiber photometry and chemo- and optogenetics. You will expose mice to models of eating disorders and address the role of specific neurons. You will be working on your own project, supported by technicians and surrounded by a team of PhD students and postdocs who are working with similar and related technologies.
The department of translational neuroscience is the preclinical department of the brain division at the University Medical Center Utrecht. The department’s research mission is to discover and delineate mechanisms and processes fundamental to the development of neural systems and to the control of behavior and to translate these to pathogenesis and disease models. The Department has the unique advantage of being embedded in the clinical environment of UMCU and having a multidisciplinary character. Its toolkit includes lightsheet microscopy, optogenetics, electrophysiology, and scRNAseq, its own animal facility, viral vector generation and more. The research group run by Roger Adan studies the neural circuits involved in eating disorders.
As a candidate suitable for this position, you are a neurobiologist interested to work with rodents and your communicative skills are strong. You must be able to demonstrate an affinity for the study of neural circuits and have or acquire a license to work with animals. Valued qualities include an interest in translational research and the ambition to further develop yourself as a molecular neuroscientist.
You will be required to work in a team in a collaborative manner and help other members in the team.
For this 100% post, salary is according to academic scales. This will be a temporary appointment for 4 years.
We believe in the power of a diverse team in which there is room for different skills, expertise, and social and cultural backgrounds. We invite you to respond to this vacancy.
The maximum salary for this position (36 hours) is € 3.271,00 gross per month based on full-time employment.
In addition, we offer an annual benefit of 8.3%, holiday allowance, travel expenses and career opportunities. The terms of employment are in accordance with the Cao University Medical Centers (UMC).
If you have any questions about this vacancy, please contact Roger Adan, Hoogleraar moleculaire farmacologie, phone number: 030 253 8517, e‑mail adress: [email protected].
Acquisition based on this jobopening is not appreciated.