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    Full-time Position
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    Supply Chain & Logistics
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  • Degree Required
    • Province
    • Date Posted
      August 27,2022
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    PhD candidate ‘MRI-guided radioembolization’

    3 years Your PhD project will focus on developing and testing of a unique, MRI-guided radioembolization procedure. Will you join our ambitious team?

    The project MRI guided radioembolization is divided in three major subprojects in which the technical aspects are developed that are necessary for real-time MRI-guided radioembolization:
    • Development of an MRI-compatible and visible catheter
    • Complementary machine learning algorithms for visualization of the catheter
    • Fast dosimetry software to guide treatment
    These three technical aspects must be combined and tested in phantoms, ex-vivo livers, animal studies and ultimately patients. Combining these techniques will be the main focus of your project within the Radboudumc. Click here to read more about the project.

    The main tasks for you will be to perform the preclinical proof-of-concept: In line with the technology framework for MRI-guided interventional procedures, you will optimize our workflow for perfused phantom testing using (radioactive) microspheres and catheters. The catheters will be equipped with an MR marker, which can be tracked on MRI. These studies will allow assessment of MR safety, visibility and dose estimation capabilities of the DELIVR solution. The phantom results are also necessary to optimize the catheter coating and tracking software parameters. Animal experiments using pig models will be performed to gather the data needed for entering clinical evaluation phase.

    You will be positioned in the MAGIC research group of Dr. Frank Nijsen and Prof. Dr. Jurgen Fütterer at the department of Medical Imaging, Radboudumc in Nijmegen and you will be part of a dynamic, multidisciplinary team. Within this project you will work together with several colleague PhD candidates, senior researchers, intervention radiologists, nuclear medicine physicians and the R&D officers of three different commercial partners. Preclinical work and the validation on patients treated with radioembolization will be performed in the Radboudumc.

    Tasks and responsibilities
    • Processing and analysis of imaging data and the set-up of a detailed project planning.
    • Phantom development and testing of catheters and software in different MRI environments.
    • The development of the unique image guided radioembolization procedure in phantoms, ex-vivo and in-vivo animal model.
    • Evaluation of safety and accuracy of the image guided treatment.
    • Determine precision of the tracking software and catheter visualization.
    • Report in collaboration with a multidisciplinary group on a modified Failure Mode and Effect Analysis (FMEA).
    • Coordination and communication with the collaborating partners.
    • Reporting and writing scientific publications in English.
    • Present findings at (inter)national scientific meetings, within the project consortium and patient groups.
    • Writing the project plan for animal studies and get Animal Ethics Committee approval.
    • Work in a team with other scientists and clinicians to plan, discuss, and perform research in a stimulating environment.
    The salary depends on education. Scale 10 will be offered to MSc medical graduates; those holding degrees in other disciplines will be offered scale 10A.

    Working at Radboud university medical center means that you are ahead of the curve and working together on the healthcare of the future. And there is more. Our secondary terms of employment are impressive. These are fully tailored to you thanks to our Employment Conditions Selection Model. At Radboud university medical center, you will be given trust, and you will take the responsibility to handle everything together. We provide annual courses, both professional and personal.
    • A gross monthly salary between € 2.631 and € 4.800 (scale 10A or scale 10) based on full-time employment.
    • An annual vacation allowance of 8% and an end-of-year bonus of 8.3%.
    • If you work irregular hours, you will receive an allowance.
    • As a full-time employee (36 hours per week), you are entitled to approximately 168 vacation hours (over 23 days) per year.
    • Radboud university medical center pays 70% of the pension premium. You pay the rest of the premium with your gross salary.
    • You get a discount on health insurance as well: you can take advantage of two group health insurance plans. UMC Zorgverzekering and CZ collectief.
    In addition to our terms of employment, we also offer employees various other attractive facilities, such as childcare and sports facilities. Want to learn more? Take a look at the Cao UMC. The Department of Medical Imaging of the Radboudumc Nijmegen is headed by Prof. Dr. Mathias Prokop. The Radboudumc is an academic center with focus on research, education and patient care. The department has extensive expertise in imaging and uses state-of the art CT, ultrasound, MRI and nuclear imaging. Advanced MRI facilities for both patient care and (animal experiments) research are available and accessible. Within the Department of Radiology oncology is an important focus of research and patient care. Both pre-clinical and clinical research can be performed in the animal lab (PRIME) and in the Medical Innovation & Technology expert Centre (MITeC), which is a conglomerate of three Operating Rooms (OR’s) in the newly built OR-complex in the Radboudumc.

    Our project DELIVR
    Each year, over 1.5 million patients worldwide develop liver tumors. Radioembolization, also called Selective Internal Radiation Therapy (SIRT), is a treatment option for patients suffering from liver tumors that do not benefit from conventional therapy. During the treatment, radioactive microspheres are injected into the liver artery that supplies the tumor, where they lodge in and around the tumor and deliver a high local radiation dose. Radioembolization has emerged as a promising treatment modality in inoperable primary liver malignancies. However, challenges related to imprecise radiation dose estimation and difficulties in delivering the radiation accurately at the tumor location have hampered its full-scale clinical adoption. We aim to meet these challenges with the fully MRI guided Radioembolization technique at a standard MRI apparatus. Therefore, we will develop within an European Eurostars project, a turn-key platform – DELIVR - for precision radiation dosing in MRI-guided Radioembolization for liver tumors.

    Research Institutes
    At the moment there are more than 1,300 PhD candidates at our medical hospital. This number includes PhD candidates on our pay roll as well as external candidates (those employed somewhere else but researching on our premises). Read what it is like to do a PhD at the Radboud University Medical Center.

    Radboud university medical center is a university medical center for patient care, scientific research, and education in Nijmegen. Radboud university medical center strives to be at the forefront of shaping the healthcare of the future. We do this in a person-centered and innovative way, and in close collaboration with our network. We want to have a significant impact on healthcare. We want to improve with each passing day, continuously working towards better healthcare, research, and education. And gaining a better understanding of how diseases arise and how we can prevent, treat, and cure them, day in and day out. This way, every patient always receives the best healthcare, now and in the future. Because that is why we do what we do.

    Read more about our strategy and what working at Radboud university medical center means. Our colleagues would be happy to tell you about it. #weareradboudumc You have a Master’s degree in Technical Medicine or Biomedical Engineering and affinity with experiments in that area. You are eager to work on this multi-disciplinary translational project, consisting of in-depth pre-clinical feasibility and modelling studies in a laboratory and medical imaging environment, combined with patient-related clinical research.

    • An interest in high-tech medicine and medical physics.
    • Affinity with translational research which will have direct impact on future medical procedures.
    • Affinity with medical imaging, segmentation, optimization of imaging processing for real-time visualization.
    • Experience with and/or interest in interventional MRI guided procedures
    • Interest in exploring and testing catheter visualization and navigation techniques on MRI.
    • Well-developed communicational and social skills directed towards working in an international team.
    • Enthusiastic and strong motivation to successfully complete a PhD in 3 years.
    • Experience with programming in Matlab, Python or comparable languages
    • Permit to work with radioactivity (or willing to obtain this permit).
    • Permit to work with laboratory animals; article-9 (or willing to obtain this permit).
    ny questions? Please contact Dr. Frank Nijsen or Prof.Dr. Jurgen Fütterer .Use the Apply button to submit your application. Use the Apply button to submit your application.
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