4 years In this PhD project we aim a better understanding of the mechanisms involved in immunotherapy-related toxicity, with a focus on T-cell behavior. We will conduct a clinical study with translational research. We will use several innovative technologies in the domains of imaging, immunology, genomics, and pathology to obtain in-depth insights in the factors underlying the early development of immunotherapy-related toxicities. Will you join our team?
Immune checkpoint inhibitors, such as anti-programmed cell death-1 (PD-1), anti-programmed
cell death ligand-1 (PD-L1), and anti-cytotoxic T-lymphocyte antigen-4 (CTLA-4), have revolutionized the treatment of cancer in the past decades. Immune therapy resulted in overall survival benefit for patients with advanced stage cancer, and have become standard of care in several cancer types.
Immune checkpoint inhibitors release the brake of the immune system during priming of naive T-cells and during reactivation of memory anti-cancer T-cell responses. However, this systemic activation of immune cells and induction of potentially self-reactive T-cells also leads to off-target activity, so-called immunotherapy-related toxicity. Combined treatment with anti-CTLA-4 and anti-PD-1 antibodies leads to severe toxicity in more than half of the patients.
Tasks and responsibilities
Coordinate and control our site-specific immunotherapy-related toxicity trial (planning of study activities and to obtain biopsy material, blood, stool samples, etc).
Acquire knowledge of PET imaging and perform quantitative analyses.
Acquire knowledge of diverse laboratory techniques, including multi-dimensional flowcytometry and multi-colour immunohistochemistry, and perform quantitative analyses.
Actively participate in multi-disciplinary scientific meetings (laboratory meetings).
The salary depends on education. Scale 10 will be offered to MSc medical graduates; those holding degrees in other disciplines will be offered scale 10A.
Working at Radboud university medical center means that you are ahead of the curve and working together on the healthcare of the future. And there is more. Our secondary terms of employment are impressive. These are fully tailored to you thanks to our Employment Conditions Selection Model. At Radboud university medical center, you will be given trust, and you will take the responsibility to handle everything together. We provide annual courses, both professional and personal.
In addition to your monthly salary and an annual vacation allowance of 8%, you will receive an end-of-year bonus of 8.3%.
If you work irregular hours, you will receive an allowance.
As a full-time employee (36 hours per week), you are entitled to approximately 168 vacation hours (over 23 days) per year.
Radboud university medical center pays 70% of the pension premium. You pay the rest of the premium with your gross salary.
You get a discount on health insurance as well: you can take advantage of two group health insurance plans. UMC Zorgverzekering and CZ collectief.
In addition to our terms of employment, we also offer employees various other attractive facilities, such as childcare and sports facilities. Want to learn more? Take a look at the Cao UMC. The Department of Medical Imaging and department of Medical Oncology are part of the Radboudumc Center for Oncology. We emphasize on working in multidisciplinary teams to improve both patient care as well as research. The nursing department, day care and outpatient clinic are all integrated to guarantee a well streamlined process in the treatment for our patients.
Embedded in our academic patient care are early stage clinical trials, and translational research regarding pharmacology, pathology, genetics, radiology, nuclear medicine and tumour immunology. Both the department of Medical Imaging and department of Medical Oncology have a close relation with the department of Tumor Immunology focussing on translational research. The department of Tumor Immunology is embedded within the Radboud Institute for Molecular Life Sciences (RIMLS), a leading European research school that provides an outstanding, multi-cultural and thriving research setting within the Radboudumc.
The Radboudumc aims to excel in all academic tasks and in giving the patient an important voice in the treatment team. To act together within networks and partnerships are topical issues of the Radboudumc subjects for giving shape to an optimal organization of sustainable oncology care.
At the moment there are more than 1,300 PhD candidates at our medical hospital. This number includes PhD candidates on our pay roll as well as external candidates (those employed somewhere else but researching on our premises).
Radboud Institute for Health Sciences: ± 700
Radboud Institute for Molecular Life Sciences: ± 400
Donders Center for Medical Neurosciences: ± 200
Read what it is like to do a PhD at the Radboud University Medical Center.
Radboud university medical center is a university medical center for patient care, scientific research, and education in Nijmegen. Radboud university medical center strives to be at the forefront of shaping the healthcare of the future. We do this in a person-centered and innovative way, and in close collaboration with our network. We want to have a significant impact on healthcare. We want to improve with each passing day, continuously working towards better healthcare, research, and education. And gaining a better understanding of how diseases arise and how we can prevent, treat, and cure them, day in and day out. This way, every patient always receives the best healthcare, now and in the future. Because that is why we do what we do.
Read more about our strategy and what working at Radboud university medical We are looking for a motivated medical doctor or technical physician with affinity with immunology and medical imaging. You have a master degree in Medicine or Technical Medicine with special interest in translational research or you have a master degree in Biomedical sciences or equivalent with interest and experience in clinical studies.
You have some experience with immunological, cell biological and/or molecular biology techniques is an advantage. You will work in patient care, plan study-related activities, analyse PET imaging data, work with patient material, provide support in the logistics of the sample acquisition, and ultimately perform translational research in a highly motivated team of researchers.
In addition you possess the profile below:
A strong team player.
Strong analytical skills.
A high level of proficiency in English.
Able to work both independently and in a team.
A strong interest in translational research.
All additional information about the vacancy can be obtained from Dr. Harm Westdorp, internist oncologist or from Dr. Erik. Aarntzen, nuclear medical doctor. Use the Apply button to submit your application.