Job Properties
  • Job Type
    Full-time Position
  • Category
    Research & Science
  • Languages
  • Experience Required
  • Degree Required
    • Province
    • Date Posted
      December 10,2021
    • Entrusting Package
    • JSS
    • VISA
    • IMG_6430
    • Career Consultation

    Onderzoeker in opleiding (OIO) Alzheimer's disease

    About the role

    The immune system takes active part in the pathogenesis of Alzheimer’s disease. Recent evidence from the Neuro-immunology research group at Amsterdam UMC now suggests that apolipoprotein E4 (apoE4), an important genetic risk factor, plays a yet unidentified role in this process. The successful candidate will unravel if and how apoE4 drives impaired peripheral and central immune homeostasis and uncover metabolic targets to intervene with neuroinflammation and neurodegeneration in Alzheimer’s disease using a variety of in vitro and in vivo experiments with unique animal and patient material while applying high-dimensional single-cell techniques.


    We are looking for a highly driven, motivated and enthusiastic researcher with:

    • A master’s degree in a field related to biomedical sciences, neuroscience and/or immunology;
    • Affinity for immunology and neuroscience;
    • Interest in high-dimensional technologies and pushing the boundaries of research through technology-driven applications;
    • Experience with in vivo models, programming and iPSC technology is a plus;
    • Successful fulfillment of Laboratory Animal Science and obtainment of the art. 9 certificate is a plus;
    • You have a flexible, pro-active team spirit but you can also work independently;
    • Excellent communications skills in English, both written and verbal.
    • Willingness/openness to collaborate with international researchers.

    Our offer

    • We offer a four year PhD contract (starting for 12 months, to be extended for another 36 months upon evaluation).
    • Additional benefits include an 8.3% end-of-year bonus and 8.0% holiday pay.
    • Free and unlimited access to our online learning environment GoodHabitz.
    • Pension is accrued at the ABP. VUmc contributes a large part of the premium (70%).
    • In addition to excellent accessibility by public transport (partial reimbursement) we have a good bicycle scheme.
    • An active personnel association and the Young Amsterdam UMC association, both of which organise fun (sports) activities and events.

    About the project

    This project incorporates fundamental research questions as well as translational applications in in vitro and in vivo models and patient material. This project will be performed at the Neuro-immunology research group of prof. Elga de Vries in collaboration with the Immunometabolism group of dr. Jan Van den Bossche at Amsterdam UMC in the Department of Molecular Cell Biology and Immunology (location VUmc; O|2 Lab Building).

    The project is funded by a grant from Alzheimer Nederland and is embedded in the Amsterdam Neuroscience research institute.

    About the workplace

    You will work in a team with young and enthusiastic researchers, who have expertise in immunology, biochemistry, analytical chemistry, cell biology, neuroscience and neurological diseases. Research within the department Molecular Cell Biology and Immunology (VUmc) is performed in a stimulating environment and at an international high competitive level.

    Let's meet

    The intended start date for the project is March 1st 2022.

    For more information about this position, you can contact prof.dr. Elga (HE) de Vries, via +31 20 4448077 or via

    For more information about the application procedure please contact Tanja Hart, Recruitment Adviser, via T: +31 6-21603178 or E:

    A reference check, screening and hiring test may be part of the procedure. Read hier whether this also applies to you. If you join us, we ask for a VOG (Certificate of Good Conduct). Foreign citizens need to provide comparable police clearing certificates.

    Internal takes precedence over external in case of equal suitability.

    Acquisition in response to this vacancy is not appreciated.

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