uniQure is dedicated to bring innovative therapies or unmet medical needs to patients. In doing so each function in uniQure is directly or indirectly responsible for the lives of patients. This responsibility should be part of our day-to-day working life by (i) living up to high quality standards and (ii) recognizing the sense of urgency in areas of high medical need.
Place in the Organization The In Vivo Biology Group has two functions and responsibilities (a) design, execution, and reporting of efficacy in vivo studies in rodents (including dose-range finding studies), as well as (b) sample analysis to get to lead selection. The group is based in Amsterdam and Groningen, NL. his job is based in Groningen.
Purpose of the role The ideal candidate should have a deep knowledge of in vivo biology, in particular behavioral phenotyping assays, neurophysiology, and analysis of administered gene therapy in terms of both efficacy and mechanism of action. The successful candidate will have strong written and oral communication skills. We are looking for a highly motivated and skilled junior scientist with a strong background in biology to join our team.
Key result areas (major duties, accountabilities and responsibilities)
Formulates, initiates and implements research plans for proof-of-mechanism, or proof-of-concept studies in collaboration with team lead, which can be either requested by uniQure projects or necessary for improvement of existing technologies or develop new technologies Perform in-house in vivo studies utilizing behavioral, imaging/microscopy and electrophysiological assays Support in vivo technicians by executing routine procedures such as dosing, bleeding, tissue collections, and necropsies, monitor animal health, run behavioral assays, collect and record data Organizing a robust communication line to all other relevant function of the organization Organizes appropriate documentation e.g. study plans/reports and facilitates writing of regulatory documents
Qualifications & Skills MSc in biology, pharmacology, neuroscience or related field with 3-4 years of in vivo biology and/or gene therapy experience Proven scientific experience, preferably trained within the field of in vivo biology, neurobiology, neuropharmacology, immunology, gene therapy, and/or virology is a plus Animal experience (art. 9 / 12 / 13f Dutch law on animal experimentation) and deep knowledge of small animal behavior and neurophysiology is required Experience with handling of animals, animal tissues and biofluids for DNA, RNA and protein analysis under Microbiological Safety Level II restrictions Proven track record working with in vivo disease models and deep experience in performing and analyzing behavioral studies Hands-on experience in writing, presenting, and reviewing in research documents (reports, patents, publications etc.) Strong communication skills (oral and written) Experience with working in a fast changing and demanding environment, willing and able to act a pro-actively. Core competencies Creativity and explorative thinking Focus on flexibility, to act in a fast changing and demanding environment Good communication skills Thinks about new working methods or new applications Detail-oriented Ability to manage own workload as well as workload of co-workers Pro-active attitude, flexible, professional Strong team player Ability to explain complex technical issues, question, and answers in writing and orally to persons not familiar with the subject Ability to direct reports of own team Signals problems, recognizes important information, traces possible causes of problems